Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367658 | 1.00 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11031529 | 0.88 | ACE2 (0.37) | ACE2 | |
| SCHEMBL11468602 | 0.86 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11213379 | 0.84 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11269355 | 0.84 | OGA (0.35) | PDE4APDE4BPDE4CPDE4DMTNR1A | |
| SCHEMBL11090340 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10474749 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10474127 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10474878 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10474747 | 0.79 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405626-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4400385-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-08-23 | — | — | US | disclosed |
| US-4380542-A | ANALGESICS, TRANQUILIZERS | PFIZER (US) | 1983-04-19 | — | — | US | disclosed |
| US-4340737-A | CNS AGENTS, HYPOTENSIVES, DIURETICS AND AGENTS FOR TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-07-20 | — | — | US | disclosed |