Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 2/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11187654 | 0.87 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11187658 | 0.87 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11228509 | 0.86 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11367658 | 0.86 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11190084 | 0.86 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11231768 | 0.84 | OGA (0.34) | PDE4APDE4BPDE4CPDE4DNAAA | |
| SCHEMBL11252682 | 0.84 | OGA (0.34) | PDE4APDE4BPDE4CPDE4DNAAA | |
| SCHEMBL11184868 | 0.84 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11213444 | 0.84 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11090340 | 0.83 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228169-A | 1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones as antiemetic agents | PFIZER INC. (US) | 1980-10-14 | — | — | US | disclosed |