Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | BACE1 | P56817 | 7/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 6/20 | 0.56 |
| ▸ | JAK1 | P23458 | 6/20 | 0.56 |
| ▸ | TYK2 | P29597 | 6/20 | 0.56 |
| ▸ | JAK3 | P52333 | 6/20 | 0.56 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196182 | 0.90 | TLR7 (0.54) | HDAC1HDAC8BACE1NUDT1JAK2 | |
| Hydrochloric Acid SCHEMBL11202131 | 0.88 | JAK2 (0.50) | HDAC1HDAC8BACE1NUDT1JAK2 | |
| SCHEMBL11713201 | 0.83 | JAK2 (0.46) | HDAC1HDAC8BACE1NUDT1JAK2 | |
| Hydrochloric Acid SCHEMBL11195555 | 0.78 | USP2 (0.46) | HDAC1HDAC8BACE1JAK2JAK1 | |
| SCHEMBL3369348 | 0.78 | HDAC1 (0.58) | HDAC1HDAC8BACE1NUDT1JAK2 | |
| SCHEMBL3369345 | 0.77 | HDAC1 (0.64) | HDAC1HDAC8JAK2JAK1TYK2 | |
| SCHEMBL8289368 | 0.76 | HDAC1 (1.00) | HDAC1HDAC8JAK2JAK1TYK2 | |
| SCHEMBL11195213 | 0.75 | KMT2A (0.83) | BACE1NUDT1KMT2A | |
| SCHEMBL11711208 | 0.74 | TMEM97 (0.42) | HDAC1HDAC8JAK2JAK1TYK2 | |
| SCHEMBL11201306 | 0.73 | BACE1 (0.67) | HDAC1HDAC8BACE1NUDT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |
| US-4035369-A | 1-Benzazolylalkyl-4-substituted-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |