Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11193792 | 0.90 | HDAC1 (0.60) | TLR7HDAC1HDAC8JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL11195555 | 0.88 | USP2 (0.46) | TLR7HDAC1HDAC8JAK2JAK1 | |
| SCHEMBL11711208 | 0.83 | TMEM97 (0.42) | TLR7HDAC1HDAC8JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL11202131 | 0.78 | JAK2 (0.50) | TLR7HDAC1HDAC8JAK2JAK1 | |
| SCHEMBL11199159 | 0.77 | P2RX7 (0.50) | USP2POLBHRH1 | |
| SCHEMBL18547397 | 0.74 | JAK2 (0.46) | JAK2JAK1TYK2JAK3MCHR1 | |
| SCHEMBL22152472 | 0.74 | JAK2 (0.47) | TLR7HDAC1HDAC8JAK2JAK1 | |
| SCHEMBL11713201 | 0.74 | JAK2 (0.46) | HDAC1HDAC8JAK2JAK1TYK2 | |
| SCHEMBL740755 | 0.73 | HRH1 (0.52) | HRH1MCHR1 | |
| SCHEMBL740756 | 0.73 | HRH1 (0.52) | HRH1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |
| US-4035369-A | 1-Benzazolylalkyl-4-substituted-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |