Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194889 | 1.00 | TSHR (0.51) | TSHRCHRNA7ALDH1A1TDP1 | |
| SCHEMBL11193476 | 1.00 | TSHR (0.51) | TSHRCHRNA7ALDH1A1TDP1 | |
| Fumaric Acid SCHEMBL11323031 | 0.84 | ALDH1A1 (0.41) | TSHRALDH1A1TDP1 | |
| SCHEMBL20238222 | 0.79 | CHRNA7 (0.43) | TSHRCHRNA7 | |
| SCHEMBL29668812 | 0.79 | CHRNA7 (0.43) | TSHRCHRNA7 | |
| SCHEMBL29668904 | 0.79 | CHRNA7 (0.43) | TSHRCHRNA7 | |
| SCHEMBL20238323 | 0.79 | CHRNA7 (0.43) | TSHRCHRNA7 | |
| SCHEMBL10607769 | 0.75 | CHRNA7 (0.37) | TSHRCHRNA7ALDH1A1TDP1 | |
| SCHEMBL21142551 | 0.74 | CHRNA7 (0.74) | TSHRCHRNA7 | |
| SCHEMBL3402404 | 0.74 | CHRNA7 (0.74) | TSHRCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4414220-A | HUPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4333932-A | DIHYDROISOINDOLES, HYPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0010896-B1 | ORGANIC DIAMINE COMPOUNDS FOR USE AS ORAL HYPOGLYCEMIC AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4220650-A | HYPOGLYCEMIC | PFIZER INC. (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0010896-A1 | Organic diamine compounds for use as oral hypoglycemic agents and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-05-14 | — | — | EP | disclosed |