Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 9/20 | 0.50 |
| ▸ | MMP2 | P08253 | 9/20 | 0.50 |
| ▸ | MMP9 | P14780 | 9/20 | 0.50 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119957 | 1.00 | TRPV1 (0.53) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3087702 | 0.83 | TRPV1 (0.47) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3087697 | 0.83 | TRPV1 (0.47) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1119875 | 0.83 | TRPV1 (0.49) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1119870 | 0.83 | TRPV1 (0.49) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2136441 | 0.82 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL2136451 | 0.82 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL1065454 | 0.82 | F10 (0.49) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL27907216 | 0.81 | LMNA (0.44) | TRPV1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27949371 | 0.81 | MAOB (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999000-B2 | N-(2-amino-phenyl)-acrylamides | HOFFMANN-LA ROCHE INC. (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2280940-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| EP-2238103-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| US-7795315-B2 | N-(2-amino-phenyl)-amide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |
| WO-2009138338-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-19 | — | — | WO | disclosed |
| US-20090286848-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | HOFFMANN-LA ROCHE INC. | 2009-11-19 | — | — | US | disclosed |
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | US | disclosed |
| WO-2009095324-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286848-A1 | NOVEL N-(2-AMINO-PHENYL)-ACRYLAMIDES | MKI67, CCNA2, CCNA1 | TRPV1 2738/4885HDAC3 3044/4885HDAC1 1377/4885 |
| US-20090203681-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | MKI67, API5, BAD | TRPV1 2737/4885HDAC3 1401/4885HDAC1 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.