⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29231157 | 0.66 | APLNR (0.32) | — | |
| SCHEMBL28538907 | 0.63 | — | — | |
| SCHEMBL7109113 | 0.63 | — | — | |
| SCHEMBL301504 | 0.62 | — | — | |
| SCHEMBL5925239 | 0.62 | — | — | |
| SCHEMBL23648307 | 0.62 | — | — | |
| SCHEMBL6064414 | 0.60 | — | — | |
| SCHEMBL28551422 | 0.60 | — | — | |
| SCHEMBL5826028 | 0.58 | TSHR (0.32) | — | |
| SCHEMBL8062669 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131867-A1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS AND USES THEREOF | SLOAN KETTERING INST CANCER RES (US) | 2023-04-27 | — | — | US | disclosed |
| EP-3357931-B1 | METHODS OF SYNTHESIS OF TRITERPENE PROSAPOGENINS AND TRITERPENE SAPONINS | SLOAN KETTERING INST CANCER RES (US) | 2020-07-22 | — | — | EP | disclosed |
| EP-3357931-A1 | METHODS OF SYNTHESIS OF TRITERPENE PROSAPOGENINS AND TRITERPENE SAPONINS | Sloan Kettering Institute For Cancer Research (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2280987-B1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN KETTERING INST CANCER RES (US) | 2018-05-23 | — | — | EP | disclosed |
| US-20170283450-A1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS AND USES THEREOF | MEMORIAL SLOAN-KETTERING INST FOR CANCER RES (US) | 2017-10-05 | — | — | US | disclosed |
| US-9718850-B2 | Triterpene saponins, methods of synthesis and uses thereof | MEMORIAL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-08-01 | — | — | US | disclosed |
| US-20150086585-A1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS AND USES THEREOF | MEMORIAL SLOAN KETTERING INST FOR CANCER RES (US) | 2015-03-26 | — | — | US | disclosed |
| US-8889842-B2 | Triterpene saponins, methods of synthesis, and uses thereof | Sloan-Kettering Insititute for Cancer Research (US) | 2014-11-18 | — | — | US | disclosed |
| US-20130011421-A1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2013-01-10 | — | — | US | disclosed |
| US-8283456-B2 | Triterpene saponins, methods of synthesis, and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110300177-A1 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-12-08 | — | — | US | disclosed |
| EP-2280987-A2 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF | Sloan Kettering Institute For Cancer Research (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009126737-A2 | TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2009-10-15 | — | — | WO | disclosed |