Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1E | P28566 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404339 | 0.84 | SIRT1 (0.55) | SIRT1HTR2CHTR2ATP53SMN1; SMN2 | |
| SCHEMBL13925709 | 0.83 | SIRT1 (0.54) | SIRT1HTR2CHTR2ATP53HTR2B | |
| SCHEMBL8404357 | 0.83 | HTR2A (0.59) | SIRT1HTR2CHTR2ATP53SMN1; SMN2 | |
| SCHEMBL13925785 | 0.80 | HTR2A (0.58) | SIRT1HTR2CHTR2ASMN1; SMN2HTR2B | |
| SCHEMBL21758535 | 0.80 | SIRT1 (0.67) | SIRT1HTR2CHTR2AHTR2BMAPT | |
| SCHEMBL4135119 | 0.79 | SIRT1 (0.66) | SIRT1HTR2CHTR2AHTR2BMAPT | |
| SCHEMBL31120772 | 0.79 | SIRT1 (0.66) | SIRT1HTR2CHTR2AHTR2BMAPT | |
| Hydrochloric Acid SCHEMBL29896560 | 0.78 | SIRT1 (0.65) | SIRT1HTR2CHTR2AHTR2BMAPT | |
| Hydrochloric Acid SCHEMBL21957637 | 0.78 | SIRT1 (0.65) | SIRT1HTR2CHTR2AHTR2BMAPT | |
| Hydrochloric Acid SCHEMBL21957635 | 0.77 | SIRT1 (0.63) | SIRT1HTR2CHTR2AHTR2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |