SIRT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL251128	1.00	13/20
SCHEMBL222169	0.52	13/20
SCHEMBL218677	0.52	13/20
SCHEMBL219491	0.51	13/20
SCHEMBL221866	0.50	13/20
SCHEMBL222473	0.50	13/20
SCHEMBL275311	0.71	12/20
SCHEMBL236067	0.51	12/20
SCHEMBL221338	0.61	9/20
SCHEMBL341324	0.35	9/20
SCHEMBL209612	0.71	8/20
SCHEMBL150166	0.69	8/20
SCHEMBL341558	0.40	8/20
SCHEMBL203978	0.53	7/20
SCHEMBL47273	0.55	6/20
SCHEMBL130760	0.46	6/20
SCHEMBL220082	0.41	6/20
Caprolactam (SCHEMBL161418)	0.37	6/20
SCHEMBL289145	0.81	5/20
SCHEMBL289885	0.74	5/20

Clinical trials — most relevant to SIRT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
The Effect of n-3 Fatty Acid Supplementation on Serum Levels, and Gene Expression of type2 Diabetes Patient	PHASE4	UNKNOWN
Metformin in Longevity Study (MILES).	PHASE4	COMPLETED
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients	PHASE3	UNKNOWN
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Oral Nitrite for Older Heart Failure Patients	PHASE2	COMPLETED
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age	PHASE2	COMPLETED
Effect of Pioglitazone Administered to Patients With Adrenomyeloneuropathy	PHASE2	COMPLETED
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals	PHASE2	RECRUITING
The Safety and Efficacy of an NAD+ Boosting Product Together With a Low Carbohydrate Diet in Adults With Mild Hypertension and Eligible for Normal-standard-of-care	PHASE2	COMPLETED
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults	PHASE2	RECRUITING
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors	PHASE1	RECRUITING
Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)	PHASE1	COMPLETED
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Project SIRT6 Activator	nan	RECRUITING
Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery	nan	NOT_YET_RECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
How Sirtuin Levels Change During Behçet Disease	nan	UNKNOWN
Short Interval Resveratrol Trial in Cardiovascular Surgery	nan	ACTIVE_NOT_RECRUITING
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet	nan	COMPLETED
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis	nan	UNKNOWN
Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.	nan	COMPLETED
Effect of Liraglutide on Clock Genes	nan	UNKNOWN
Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS	nan	COMPLETED
Inflammation in COPD and the Effect of Nicotinamide Riboside	nan	COMPLETED
Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SIRT1 binder may also engage these)

Protein	Name	Similarity
Q923E4	—	1.000	Q923E4 →
Q9UPV7	—	0.994	Q9UPV7 →
Q5TKR9	—	0.994	Q5TKR9 →
Q99PI5	—	0.994	Q99PI5 →
BPTF	Nucleosome-remodeling factor subunit BPTF	0.993	landscape →
A0A0G2JZ79	—	0.993	A0A0G2JZ79 →
Q8WML3	—	0.993	Q8WML3 →
Q9BQK8	—	0.992	Q9BQK8 →
MAP3K13	Mitogen-activated protein kinase kinase kinase 13	0.992	landscape →
Q92539	—	0.992	Q92539 →
Q9VK34	—	0.992	Q9VK34 →
Q2PFD7	—	0.991	Q2PFD7 →
Q6ZPJ3	—	0.991	Q6ZPJ3 →
Q63553	—	0.991	Q63553 →
D3YWQ0	—	0.991	D3YWQ0 →
P58270	—	0.991	P58270 →
Q76I79	—	0.991	Q76I79 →
A7MBB4	—	0.991	A7MBB4 →
Q8BZ21	—	0.991	Q8BZ21 →
Q6PEV8	—	0.990	Q6PEV8 →
Q5JCS6	—	0.990	Q5JCS6 →
Q96PX1	—	0.990	Q96PX1 →
Q9BQI7	—	0.990	Q9BQI7 →
A6QP06	—	0.990	A6QP06 →
Q9Z148	—	0.990	Q9Z148 →
A7E379	—	0.990	A7E379 →
P56931	—	0.990	P56931 →
Q6NN85	—	0.990	Q6NN85 →
Q5R8X7	—	0.990	Q5R8X7 →
Q76N89	—	0.990	Q76N89 →