Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 18/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119612 | 0.79 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1119849 | 0.76 | OPRL1 (0.63) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1119663 | 0.72 | OPRM1 (0.67) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3413521 | 0.72 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL1119633 | 0.71 | OPRL1 (0.82) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4794542 | 0.71 | KMT2A (0.33) | — | |
| SCHEMBL13695532 | 0.70 | OPRL1 (0.79) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4014117 | 0.70 | OPRL1 (0.59) | OPRL1OPRM1OPRK1 | |
| SCHEMBL28490104 | 0.69 | KDM4E (0.53) | OPRL1 | |
| SCHEMBL22091686 | 0.68 | OPRL1 (0.58) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280941-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009118163-A1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |