Isoleucine

Isoleucine

SCHEMBL112017

C1CSCN1.CC[C@H](C)[C@H](N)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 16/20 0.43
DPP8 Q6V1X1 8/20 0.43
DPP9 Q86TI2 7/20 0.43
DPP7 Q9UHL4 7/20 0.43
SLC7A5 Q01650 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoleucine SCHEMBL480974 1.00 DPP4 (0.43) DPP4DPP8DPP9DPP7SLC7A5
Isoleucine SCHEMBL6872156 0.93 DPP4 (0.39) DPP4DPP8DPP9DPP7
Isoleucine SCHEMBL6872155 0.93 DPP4 (0.39) DPP4DPP8DPP9DPP7
Isoleucine SCHEMBL6872158 0.93 DPP4 (0.39) DPP4DPP8DPP9DPP7
Isoleucine SCHEMBL391313 0.85 DPP4 (0.70) DPP4DPP8DPP9DPP7
Valine SCHEMBL5604912 0.83 SLC7A5 (0.54) DPP4DPP8DPP7SLC7A5
Isoleucine SCHEMBL4468657 0.78 DPP4 (0.42) DPP4DPP8DPP9DPP7SLC7A5
Isoleucine SCHEMBL6428278 0.78 DPP4 (0.42) DPP4DPP8DPP9DPP7SLC7A5
Isoleucine SCHEMBL4468654 0.78 DPP4 (0.42) DPP4DPP8DPP9DPP7SLC7A5
Isoleucine SCHEMBL20340795 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1841 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3565573-B1 PAC1 RECEPTOR AGONISTS (MAXCAPS) AND USES THEREOF UNIV CALIFORNIA (US) 2023-08-23 EP claimed
EP-3565573-A2 PAC1 RECEPTOR AGONISTS (MAXCAPS) AND USES THEREOF The Regents of The University of California (US) 2019-11-13 EP claimed
US-20190322718-A1 PAC1 RECEPTOR AGONISTS (MAXCAPS) AND USES THEREOF THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS 2019-10-24 US claimed
CN-110300595-A PAC1 receptor stimulating agent (MAXCAP) and application thereof 加利福尼亚大学董事会 2019-10-01 CN claimed
WO-2018129200-A2 PAC1 RECEPTOR AGONISTS (MAXCAPS) AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-07-12 WO claimed
US-20120020930-A1 METHODS FOR THE PREPARATION OF ADIPOSE DERIVED STEM CELLS AND UTILIZING SAID CELLS IN THE TREATMENT OF DISEASES CELLERIX, S.A. (ES) 2012-01-26 US claimed
US-20110294735-A1 MECHANISM OF NEUROMEDIN U ACTION AND USES THEREOF MERCK SHARP & DOHME CORP. (US) 2011-12-01 US claimed
EP-2352512-A1 MECHANISM OF NEUROMEDIN U ACTION AND USES THEREOF Merck Sharp & Dohme Corp. (US) 2011-08-10 EP claimed
WO-2010053830-A1 MECHANISM OF NEUROMEDIN U ACTION AND USES THEREOF MERCK SHARP & DOHME CORP. (US) 2010-05-14 WO claimed
CN-101563103-A Novel nematode protein and its use in producing anthelminthic agents and vaccines MOREDUN RES INST (GB) 2009-10-21 CN claimed
EP-1448523-B1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE NOVARTIS AG (CH) 2007-08-22 EP claimed
US-20070032420-A1 Treating diabetes with glucagon-like peptide-1 secretagogues ENTELOS, INC. 2007-02-08 US claimed
WO-2006086727-A2 TREATING DIABETES WITH GLUCAGON-LIKE PEPTIDE-1 SECRETAGOGUES ENTELOS, INC. (US) 2006-08-17 WO claimed
US-7078397-B2 Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus SMITHKLINE BEECHAM CORPORATION (US) 2006-07-18 US claimed
CN-1596120-A Pharmaceutical composition for transnasal absorption DAIICHI SUNTORY PHARMA CO LTD (JP) 2005-03-16 CN claimed
US-20050014681-A1 Medicinal compositions for nasal absorption ASUBIO PHARMA CO., LTD. (JP) 2005-01-20 US claimed
EP-1466610-A1 MEDICINAL COMPOSITIONS FOR NASAL ABSORPTION Daiichi Suntory Pharma Co., Ltd. (JP) 2004-10-13 EP claimed
US-20030096328-A1 Serine/threonine hydrolase proteins and screening assays BURNHAM INSTITUTE 2003-05-22 US claimed
WO-2003023355-A2 SERINE/THREONINE HYDROLASE PROTEINS AND SCREENING ASSAYS THE BURNHAM INSTITUTE (US) 2003-03-20 WO claimed
WO-2003017936-A2 USE OF DPPIV INHIBITORS AS DIURETIC AND ANTI-HYPERTENSIVE AGENTS YALE UNIVERSITY (US) 2003-03-06 WO claimed