Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 13/20 | 0.83 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.83 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1119388 | 0.91 | CYP11B2 (1.00) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL1762421 | 0.91 | CYP11B1 (0.71) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL746915 | 0.81 | CYP11B1 (0.80) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL1119366 | 0.76 | CYP11B2 (1.00) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL1875411 | 0.73 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL3780359 | 0.70 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL8136850 | 0.70 | SMN1; SMN2 (0.40) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL1881662 | 0.69 | CYP11B2 (0.61) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL1880661 | 0.69 | CYP11B2 (0.56) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 | |
| SCHEMBL17806279 | 0.69 | CYP11B1 (0.59) | CYP11B1CYP11B2CYP1A2CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280954-A1 | 6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN ALDOSTERONE SYNTHASE CYP11B2 | Universität des Saarlandes (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009135651-A1 | 6-PYRIDIN-3-YL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN ALDOSTERONE SYNTHASE CYP11B2 | UNIVERSITÄT SAARLANDES (DE) | 2009-11-12 | — | — | WO | disclosed |