Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11201306 | 0.87 | BACE1 (0.67) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL23100606 | 0.86 | MAPT (0.53) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL13677252 | 0.83 | KMT2A (0.51) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL22777751 | 0.83 | BACE1 (0.50) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL11193333 | 0.82 | KMT2A (0.71) | MAPTTP53BACE1NUDT1KMT2A | |
| SCHEMBL11202328 | 0.81 | KDM4E (0.53) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL11201529 | 0.81 | MAPT (0.66) | MAPTTP53SMN1; SMN2KMT2AGAA | |
| SCHEMBL17876423 | 0.79 | KMT2A (0.49) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL13677244 | 0.77 | GAA (0.47) | MAPTTP53SMN1; SMN2BACE1NUDT1 | |
| SCHEMBL22788758 | 0.77 | BACE1 (0.47) | MAPTTP53SMN1; SMN2BACE1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |