Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.60 |
| ▸ | PDE4A | P27815 | 4/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10620570 | 0.84 | PDE3B (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10625021 | 0.82 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10729397 | 0.81 | PBRM1 (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10371893 | 0.78 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10353457 | 0.78 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Fumaric Acid SCHEMBL11000237 | 0.77 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Fumaric Acid SCHEMBL11000313 | 0.77 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL16157200 | 0.76 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6212361 | 0.75 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL6212364 | 0.75 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | claimed |
| EP-0090978-A2 | Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them | A. Nattermann & Cie. GmbH (DE) | 1983-10-12 | — | — | EP | disclosed |