SCHEMBL11208331

SCHEMBL11208331

COC(c1ccc(C)cc1)c1cc(C(C)(C)C)c(O)c(N)c1O

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 3/20 0.39
PTGS2 P35354 3/20 0.39
CA2 P00918 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
ALDH1A1 P00352 1/20 0.38
POLB P06746 1/20 0.38
TYR P14679 1/20 0.38
CA1 P00915 2/20 0.35
IDO1 P14902 1/20 0.34
TDO2 P48775 1/20 0.34
HSPA5 P11021 1/20 0.33
CYP2C9 P11712 5/20 0.32
CYP2C19 P33261 5/20 0.32
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32
TSHR P16473 1/20 0.32
HIF1A Q16665 2/20 0.32
MLKL Q8NB16 1/20 0.32
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11214911 0.88 CA1 (0.44) CA2SMN1; SMN2ALDH1A1CA1CYP2C9
SCHEMBL11210968 0.88 IDO1 (0.39) CA2SMN1; SMN2ALDH1A1POLBTYR
SCHEMBL11211341 0.88 CYP3A4 (0.44) CA2SMN1; SMN2ALDH1A1POLBTYR
SCHEMBL11210116 0.82 PTGS1 (0.42) PTGS1PTGS2CA2SMN1; SMN2ALDH1A1
SCHEMBL11217010 0.81 IDO1 (0.41) SMN1; SMN2POLBIDO1TDO2CYP2C9
SCHEMBL11213975 0.81 IDO1 (0.35) IDO1TDO2MLKL
SCHEMBL11212753 0.76 IDO1 (0.40) ALDH1A1TYRIDO1TDO2HIF1A
SCHEMBL11210107 0.73 CA1 (0.45) CA2ALDH1A1CA1CYP2C9CYP2C19
SCHEMBL4390429 0.71 SMN1; SMN2 (0.59) PTGS1PTGS2CA2SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL11206724 0.69 IDO1 (0.44) SMN1; SMN2IDO1TDO2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0079141-A1 Aminoresorcinol derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 1983-05-18 EP disclosed