Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 8/20 | 0.63 |
| ▸ | METAP2 | P50579 | 5/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11208569 | 0.90 | METAP1 (0.55) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL13624132 | 0.89 | METAP1 (0.64) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL3500750 | 0.87 | METAP1 (0.59) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL4369718 | 0.85 | METAP1 (0.63) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL4367996 | 0.85 | METAP1 (0.60) | METAP1METAP2CA12CA1CA2 | |
| Thiabendazole SCHEMBL28170923 | 0.84 | METAP1 (0.71) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL13624139 | 0.84 | METAP1 (0.62) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL4368728 | 0.84 | METAP1 (0.59) | METAP1METAP2CA12CA1CA2 | |
| Cambendazole SCHEMBL2895694 | 0.83 | METAP1 (0.55) | METAP1METAP2CA12CA1CA2 | |
| SCHEMBL4371759 | 0.83 | MAPT (0.59) | METAP1METAP2KDM4ETP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0090368-A1 | Anthelmintic preparations | HOECHST UK LIMITED (GB) | 1983-10-05 | — | — | EP | disclosed |