Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | GRK6 | P43250 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272946 | 0.92 | APEX1 (0.49) | APEX1GRK6ALDH1A1CYP3A4MAPT | |
| SCHEMBL21444943 | 0.80 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL2698303 | 0.80 | APEX1 (0.64) | APEX1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL2698307 | 0.80 | APEX1 (0.64) | APEX1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL19033105 | 0.78 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL9160180 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL7297826 | 0.77 | CYP3A4 (0.52) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL2340149 | 0.77 | ALDH1A1 (0.51) | ALDH1A1CYP3A4KDM4EHTTSMN1; SMN2 | |
| SCHEMBL27433521 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPTHSD17B10HTTLMNA | |
| SCHEMBL31580183 | 0.77 | ALDH1A1 (0.48) | ALDH1A1CYP3A4MAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039440-B1 | MEDICINES CONTAINING SUBSTITUTED BENZOTHIAZOL-2-(3H)-ONES | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| US-4353919-A | Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-10-12 | — | — | US | disclosed |
| EP-0039440-A1 | Medicines containing substituted benzothiazol-2-(3H)-ones | Dr. Karl Thomae GmbH (DE) | 1981-11-11 | — | — | EP | disclosed |