Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617255 | 0.77 | MEN1 (0.38) | NOTUMMAPTTSHRHDAC3HDAC4 | |
| SCHEMBL4616310 | 0.74 | POLB (0.50) | POLBMAPTTSHRNPSR1ALDH1A1 | |
| SCHEMBL9806019 | 0.73 | ASAH1 (0.47) | POLBMAPTNPSR1CYP1A2CYP3A4 | |
| SCHEMBL9806051 | 0.72 | HTT (0.48) | TSHRNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL22045678 | 0.66 | PARP1 (0.36) | NOTUMPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL3314327 | 0.64 | POLB (0.61) | NOTUMPOLBMAPTTSHRNPSR1 | |
| SCHEMBL11397522 | 0.63 | PARP10 (0.46) | NOTUMPOLBTSHRHDAC3HDAC4 | |
| SCHEMBL5277846 | 0.63 | MAPT (0.40) | NOTUMMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17621007 | 0.62 | KDM4E (0.37) | TSHRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11649328 | 0.61 | PTGS2 (0.35) | POLBMAPTTSHRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039440-B1 | MEDICINES CONTAINING SUBSTITUTED BENZOTHIAZOL-2-(3H)-ONES | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| US-4353919-A | Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-10-12 | — | — | US | disclosed |
| EP-0039440-A1 | Medicines containing substituted benzothiazol-2-(3H)-ones | Dr. Karl Thomae GmbH (DE) | 1981-11-11 | — | — | EP | disclosed |