Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 1/20 | 0.66 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | TACR2 | P21452 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SHBG | P04278 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157114 | 1.00 | P2RY6 (0.66) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL18245390 | 1.00 | P2RY6 (0.66) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL11856911 | 0.98 | P2RY6 (0.68) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9347524 | 0.95 | P2RY6 (0.59) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL16215345 | 0.95 | P2RY6 (0.59) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL1274079 | 0.94 | P2RY6 (0.62) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9347327 | 0.93 | P2RY6 (0.61) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL1457664 | 0.93 | P2RY6 (0.70) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL7652716 | 0.90 | P2RY6 (0.58) | P2RY6ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL29306033 | 0.88 | P2RY6 (0.63) | P2RY6CYP3A4HSD17B10ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021806-B1 | 2,3-DIHYDRO-IMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-12 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |
| EP-0021806-A1 | 2,3-Dihydro-imidazo (2,1-b) benzothiazole derivatives and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |