SCHEMBL7652716

SCHEMBL7652716

CCCCCc1ccc(C#Cc2ccc(N=C=S)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 1/20 0.58
HSD17B10 Q99714 2/20 0.46
TSHR P16473 1/20 0.46
CYP3A4 P08684 4/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C9 P11712 2/20 0.43
ALDH1A1 P00352 3/20 0.42
ESR1 P03372 2/20 0.42
ADRA2A P08913 2/20 0.42
ADORA3 P0DMS8 2/20 0.42
TACR2 P21452 2/20 0.42
SLC6A2 P23975 2/20 0.42
SLC6A4 P31645 2/20 0.42
SLC6A3 Q01959 2/20 0.42
LMNA P02545 2/20 0.42
KDM4E B2RXH2 1/20 0.42
SHBG P04278 1/20 0.42
TP53 P04637 1/20 0.42
HSPD1 P10809 1/20 0.42
ADRB3 P13945 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29305831 0.96 HSD17B10 (0.54) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL29200032 0.95 P2RY6 (0.59) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL11856911 0.92 P2RY6 (0.68) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL29305830 0.91 P2RY6 (0.54) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL6157114 0.90 P2RY6 (0.66) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL11210604 0.90 P2RY6 (0.66) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL18245390 0.90 P2RY6 (0.66) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL28300020 0.89 P2RY6 (0.46) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL28916673 0.89 P2RY6 (0.46) P2RY6HSD17B10TSHRCYP3A4CYP2D6
SCHEMBL9347327 0.87 P2RY6 (0.61) P2RY6HSD17B10TSHRCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11279878-B2 Birefringent liquid crystal composition comprising alkylsulfanylaryl isothiocyanato tolane compounds ESSILOR INTERNATIONAL (FR) 2022-03-22 US claimed
EP-3394206-B1 BIREFRINGENT LIQUID CRYSTAL COMPOSITION COMPRISING ALKYLSULFANYLARYL ISOTHIOCYANATO TOLANE COMPOUNDS ESSILOR INT (FR) 2021-05-05 EP claimed
US-20180371317-A1 BIREFRINGENT LIQUID CRYSTAL COMPOSITION COMPRISING ALKYLSULFANYLARYL ISOTHIOCYANATO TOLANE COMPOUNDS ESSILOR INTERNATIONAL (FR) 2018-12-27 US claimed
EP-3394206-A1 BIREFRINGENT LIQUID CRYSTAL COMPOSITION COMPRISING ALKYLSULFANYLARYL ISOTHIOCYANATO TOLANE COMPOUNDS Essilor International (FR) 2018-10-31 EP claimed
WO-2017109534-A1 BIREFRINGENT LIQUID CRYSTAL COMPOSITION COMPRISING ALKYLSULFANYLARYL ISOTHIOCYANATO TOLANE COMPOUNDS Essilor International (Compagnie Générale d'Optique) (FR) 2017-06-29 WO claimed
EP-2799516-A1 LIQUID CRYSTAL MATERIAL OF SMECTIC PHASE IN HIGH SCATTERING STATE AND DISPLAY DEVICE THEREOF Halation Photonics Corporation (CN) 2014-11-05 EP disclosed
EP-0530338-B1 ANISOTROPIC ORGANIC COMPOUNDS QINETIQ LTD (GB) 2002-05-02 EP disclosed
US-5888421-A LIQUID CRYSTALS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1999-03-30 US disclosed
EP-0530338-A1 ANISOTROPIC ORGANIC COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN (GB) 1993-03-10 EP disclosed
WO-1992016519-A2 ANISOTROPIC ORGANIC COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1992-10-01 WO disclosed