Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207896 | 0.84 | MAPK1 (0.44) | HSD17B10MAPK1ADRA2AADRA2BADRA2C | |
| SCHEMBL11214565 | 0.75 | CYP1A2 (0.48) | HSD17B10MAPK1GAACYP1A2POLB | |
| SCHEMBL24094357 | 0.72 | JAK2 (0.41) | ROCK1 | |
| SCHEMBL11215757 | 0.68 | ALDH1A1 (0.44) | HSD17B10MAPK1ADRA2AADRA2BADRA2C | |
| SCHEMBL11544897 | 0.66 | MAPK1 (0.62) | HSD17B10MAPK1ADRA2AADRA2BADRA2C | |
| SCHEMBL20611868 | 0.65 | SYK (0.48) | ROCK1 | |
| SCHEMBL8404436 | 0.64 | IDO1 (0.46) | MAPT | |
| SCHEMBL5415101 | 0.63 | ROCK1 (0.41) | ROCK1 | |
| SCHEMBL24933983 | 0.62 | ROCK1 (0.39) | GAACYP1A2POLBROCK1RAB9A | |
| SCHEMBL21259093 | 0.62 | TNIK (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333945-A | Thiazoline and imidazoline derivatives useful as minor tranquilizers | SANDOZ LTD. (CH) | 1982-06-08 | — | — | US | disclosed |
| US-4329354-A | HAVING A 2,1,3-BENZOTHIADIAZOLE COMPONENT | SANDOZ LTD. (CH) | 1982-05-11 | — | — | US | disclosed |