Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 4/20 | 0.44 |
| ▸ | HMGCR | P04035 | 3/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11209029 | 0.98 | PTPN7 (0.47) | PTPN7HMGCRPAOXCHRM1ALDH1A1 | |
| SCHEMBL11287906 | 0.80 | PTPN7 (0.45) | PTPN7HMGCRPAOXCHRM1ALDH1A1 | |
| SCHEMBL11275656 | 0.80 | PTPN7 (0.61) | PTPN7HMGCRALDH1A1RECQLTDP1 | |
| SCHEMBL14369459 | 0.78 | PTPN7 (0.70) | PTPN7HMGCRALDH1A1RECQLTDP1 | |
| SCHEMBL5129481 | 0.78 | PTPN7 (0.70) | PTPN7HMGCRALDH1A1RECQLTDP1 | |
| SCHEMBL11210943 | 0.78 | PTPN7 (0.48) | PTPN7HMGCRPAOXCHRM1ALDH1A1 | |
| SCHEMBL11795105 | 0.78 | PTPN7 (0.64) | PTPN7HMGCRALDH1A1RECQLTDP1 | |
| SCHEMBL11282688 | 0.78 | TSHR (0.52) | PTPN7HMGCRALDH1A1RECQLMEN1 | |
| SCHEMBL16477771 | 0.77 | PAOX (0.44) | PTPN7HMGCRPAOXCHRM1ALDH1A1 | |
| SCHEMBL11730592 | 0.77 | PTPN7 (0.52) | PTPN7HMGCRPAOXCHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007180-B1 | PROSTAGLANDIN ANALOGUE TRIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1983-03-30 | — | — | EP | disclosed |
| US-4294972-A | ANTIULCER AGENTS, CARDIOVASCULAR DISORDERS | BEECHAM GROUP LIMITED (GB) | 1981-10-13 | — | — | US | disclosed |
| EP-0007180-A1 | Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them | BEECHAM GROUP PLC (GB) | 1980-01-23 | — | — | EP | disclosed |