Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RGS4 | P49798 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212262 | 0.86 | TDP1 (0.36) | SMN1; SMN2TDP1L3MBTL1USP2RGS4 | |
| SCHEMBL11312854 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL11216028 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2USP2ALDH1A1KDM4ELMNA | |
| SCHEMBL11376315 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1USP2ALDH1A1LMNA | |
| SCHEMBL9003814 | 0.71 | TOP2A (0.40) | SMN1; SMN2TDP1L3MBTL1RGS4ALDH1A1 | |
| SCHEMBL11691595 | 0.69 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1USP2ALDH1A1LMNA | |
| SCHEMBL11312852 | 0.68 | SMN1; SMN2 (0.36) | SMN1; SMN2L3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL18029436 | 0.66 | TDP1 (0.63) | SMN1; SMN2TDP1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10361075 | 0.64 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL11362453 | 0.62 | SRC (0.34) | L3MBTL1KDM4EMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| EP-0002605-B1 | CEPHALOSPORIN COMPOUNDS AND FORMULATIONS CONTAINING THEM FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS AND THE PREPARATION OF THE CEPHALOSPORIN COMPOUNDS | ELI LILLY AND COMPANY (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4200745-A | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins | ELI LILLY AND COMPANY (US) | 1980-04-29 | — | — | US | disclosed |
| EP-0002605-A1 | Cephalosporin compounds and formulations containing them for use in the treatment of bacterial infections and the preparation of the cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1979-06-27 | — | — | EP | disclosed |
| US-4061861-A | ANTIBIOTIC | ELI LILLY AND COMPANY (US) | 1977-12-06 | — | — | US | disclosed |
| US-4048161-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |