Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212806 | 0.83 | APEX1 (0.42) | ALDH1A1SMN1; SMN2APEX1BCL2MAPT | |
| SCHEMBL7221835 | 0.83 | APEX1 (0.42) | ALDH1A1SMN1; SMN2APEX1BCL2MAPT | |
| SCHEMBL11214282 | 0.77 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2APEX1KDM4EMAPT | |
| SCHEMBL29650224 | 0.77 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2APEX1KDM4EMAPT | |
| SCHEMBL11218173 | 0.76 | TP53 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTDDB1 | |
| SCHEMBL12251567 | 0.76 | TP53 (0.42) | BCL2MAPTEPHX2SIGMAR1DDB1 | |
| SCHEMBL11217165 | 0.76 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2APEX1KDM4EFFAR1 | |
| SCHEMBL11212191 | 0.76 | EPHX1 (0.49) | ALDH1A1SMN1; SMN2APEX1KDM4EFFAR1 | |
| SCHEMBL15741849 | 0.75 | MTNR1A (0.57) | SMN1; SMN2KDM4EMAPTLMNAKMT2A | |
| SCHEMBL27767076 | 0.75 | MAPT (0.42) | ALDH1A1SMN1; SMN2BCL2MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |