SCHEMBL112153

SCHEMBL112153

CCC(O)(O)C1NC(=O)NC1=O

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.40
HSD17B10 Q99714 1/20 0.36
LMNA P02545 2/20 0.34
ALDH1A1 P00352 2/20 0.33
MAPT P10636 1/20 0.33
RGS12 O14924 1/20 0.32
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL941641 0.78 TSHR (0.41) TSHRHSD17B10LMNAALDH1A1MAPT
SCHEMBL10914312 0.77 TSHR (0.44) TSHRHSD17B10LMNARGS12
SCHEMBL6413977 0.76 TSHR (0.40) TSHRHSD17B10LMNAALDH1A1MAPT
SCHEMBL8991930 0.75 HSD17B10 (0.42) TSHRHSD17B10LMNAALDH1A1HTT
SCHEMBL7760124 0.72 TSHR (0.40) TSHRHSD17B10LMNARGS12GAA
SCHEMBL11506612 0.72 TSHR (0.33) TSHRHSD17B10LMNA
SCHEMBL8415882 0.72 TSHR (0.48) TSHRLMNAALDH1A1MAPTRGS12
SCHEMBL3877151 0.72 TSHR (0.48) TSHRLMNAALDH1A1MAPTRGS12
SCHEMBL8413794 0.72 TSHR (0.48) TSHRLMNAALDH1A1MAPTRGS12
SCHEMBL11505915 0.70 TSHR (0.32) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12173178-B2 Polyfunctional hydrazide crosslinker PPG INDUSTRIES OHIO, INC. (US) 2024-12-24 US disclosed
US-20240117215-A1 POLYFUNCTIONAL HYDRAZIDE CROSSLINKER PPG INDUSTRIES OHIO, INC. (US) 2024-04-11 US disclosed
US-20230220219-A1 COMPOSITIONS CONTAINING THERMALLY CONDUCTIVE FILLERS PPG INDUSTRIES OHIO, INC. (US) 2023-07-13 US disclosed
US-20230120549-A1 Polyurethanes, Articles and Coatings Prepared Therefrom and Methods of Making the Same PPG INDUSTRIES OHIO, INC. 2023-04-20 US disclosed
US-11591436-B2 Polyurethane article and methods of making the same PPG INDUSTRIES OHIO, INC. (US) 2023-02-28 US disclosed
US-11472912-B2 Polyurethanes, articles and coatings prepared therefrom and methods of making the same PPG INDUSTRIES OHIO, INC. (US) 2022-10-18 US disclosed
US-20220119581-A1 Aircraft Windows PPG INDUSTRIES, INC. 2022-04-21 US disclosed
US-20220112328-A1 \"Polyurethanes, Articles and Coatings Prepared Therefrom and Methods of Making the Same\ PPG INDUSTRIES OHIO, INC. 2022-04-14 US disclosed
US-11248083-B2 Aircraft windows PPG INDUSTRIES OHIO, INC. (US) 2022-02-15 US disclosed
WO-2021211182-A1 COMPOSITIONS CONTAINING THERMALLY CONDUCTIVE FILLERS PPG INDUSTRIES OHIO, INC. (US) 2021-10-21 WO disclosed
US-4798745-A CROSSLINKING A MALEIC ANHYDRIDE COPOLYMER PPG INDUSTRIES, INC. (US) 1989-01-17 US disclosed
US-4798746-A Basecoat/clearcoat method of coating utilizing an anhydride additive in the thermoplastic polymer-containing basecoat for improved repairability PPG INDUSTRIES, INC. (US) 1989-01-17 US disclosed
US-4749803-A Reaction products of mercapto-functional monohydric alcohols and vinyl silanes, and NCO-functional compounds therefrom PPG INDUSTRIES, INC. (US) 1988-06-07 US disclosed
US-4720534-A NCO-terminated compounds from adducts of mercapto-functional polyhydric alcohols and vinyl-type silanes containing hydrolyzable groups PPG INDUSTRIES, INC. (US) 1988-01-19 US disclosed
EP-0231514-A2 Compositions based on resins having silicon atoms attached to hydrolyzable groups derived from vinyl silanes and mercaptofunctional compounds PPG INDUSTRIES, INC. (US) 1987-08-12 EP disclosed
EP-0229390-A2 Reaction products of mercapto-functional monohydric alcohols and vinyl silanes, and NCO-functional compounds therefrom PPG INDUSTRIES, INC. (US) 1987-07-22 EP disclosed
US-4652610-A FLEXIBLE COATINGS; AUTOMOBILE PAINTS PPG INDUSTRIES, INC. (US) 1987-03-24 US disclosed
US-4652664-A Addition products prepared from mercapto-functional polyhydric alcohols and vinyl-type silanes containing hydrolyzable groups PPG INDUSTRIES, INC. (US) 1987-03-24 US disclosed
EP-0212063-A1 Urethane resins containing hydrolyzable moieties from organosilane compounds PPG INDUSTRIES, INC. (US) 1987-03-04 EP disclosed
US-4622369-A Urethane resins containing hydrolyzable moieties from organosilane compounds PPG INDUSTRIES, INC. (US) 1986-11-11 US disclosed