SCHEMBL11217519

SCHEMBL11217519

NC(=O)C(Sc1ccc(Cl)cc1)c1cc(Cl)cc(C(=O)c2ccccc2)c1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100B P04271 1/20 0.40
MAPK14 Q16539 1/20 0.40
MAPT P10636 3/20 0.39
TRPA1 O75762 1/20 0.39
NR4A1 P22736 1/20 0.39
ALOX15 P16050 2/20 0.39
HTT P42858 2/20 0.38
LMNA P02545 2/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MITF O75030 1/20 0.38
HSP90AA1 P07900 1/20 0.38
ATM Q13315 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TLR9 Q9NR96 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GABRP O00591 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11224675 0.95 ALOX15 (0.40) S100BMAPK14MAPTALOX15HTT
SCHEMBL1569040 0.84 ALOX15 (0.41) S100BMAPK14MAPTALOX15HTT
SCHEMBL11227083 0.82 NR4A1 (0.46) MAPK14MAPTNR4A1ALOX15LMNA
SCHEMBL1569323 0.78 MAPT (0.44) MAPK14MAPTHTTLMNATSHR
SCHEMBL11229013 0.75 MAPT (0.40) S100BMAPK14MAPTALOX15HTT
SCHEMBL11219737 0.73 RECQL (0.43) MAPTHTTTSHRMAPK1ALDH1A1
SCHEMBL11559710 0.72 EPHX1 (0.57) MAPTTRPA1HTTLMNAMAPK1
SCHEMBL27536792 0.72 MAPT (0.40) S100BMAPK14MAPTALOX15HTT
SCHEMBL9747349 0.71 PTGS1 (0.43) MAPTNR4A1
SCHEMBL23337438 0.71 MAPT (0.55) S100BMAPK14MAPTNR4A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4313949-A Method of producing an inhibitory effect on blood platelet aggregation A. H. ROBINS COMPANY, INC. (US) 1982-02-02 US disclosed