Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5181288 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| Propylene Glycol SCHEMBL28804501 | 1.00 | TDP1 (0.71) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL19856450 | 0.97 | TDP1 (0.67) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| Propylene Glycol SCHEMBL27908921 | 0.97 | TDP1 (0.67) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL4893040 | 0.94 | TDP1 (0.62) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL531424 | 0.93 | TDP1 (0.71) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL28655257 | 0.93 | TDP1 (0.71) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL27302584 | 0.93 | TDP1 (0.71) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,5-Pentanediol SCHEMBL9343564 | 0.90 | TDP1 (0.67) | TDP1TSHRALDH1A1SMN1; SMN2LMNA | |
| 1,4-Butanediol SCHEMBL11103432 | 0.90 | TDP1 (0.67) | TDP1TSHRALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303784-A1 | PROCESS FOR PRODUCING A NON-FLAT ARTICLE | Plantics Holding B.V. (NL) | 2023-09-28 | — | — | US | claimed |
| US-8557553-B2 | Nuclease reduction | NOVOZYMES A/S (DK) | 2013-10-15 | — | — | US | claimed |
| EP-2382295-A1 | CLEANER COMPOSITIONS OF SULFONATED ESTOLIDES AND USES THEREOF | STEPAN COMPANY (US) | 2011-11-02 | — | — | EP | claimed |
| EP-1419189-B1 | PROCESS TO MANUFACTURE FLEXIBLE POLYURETHANE FOAMS | DOW GLOBAL TECHNOLOGIES INC (US) | 2011-02-09 | — | — | EP | claimed |
| US-20090312485-A1 | UNSATURATED POLYESTER RESIN COMPOSITIONS COMPRISING 1,3-PROPANEDIOL | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-12-17 | — | — | US | claimed |
| US-20090249950-A1 | CROSSLINKED MEMBRANE AND POLYMER FOR MAKING SAME AND METHOD OF USING MEMBRANE | CHEVRON U.S.A. INC. (US) | 2009-10-08 | — | — | US | claimed |
| US-20090054837-A1 | Coating Method for a Folded Balloon | B. BRAUN MELSUNGEN AG (DE) | 2009-02-26 | — | — | US | claimed |
| US-20060156952-A1 | Weatherability, optical density and sticking recovery property of nozzles of a recording head | CANON KABUSHIKI KAISHA (JP) | 2006-07-20 | — | — | US | claimed |
| US-6534624-B2 | Depolymerization and esterification of terephthalate polyesters recovered from waste materials and regenerated, in a mixture of tetra- or higher alcohol, an oil and fat and/or a fatty acid, and a polybasic acid | KANSAI PAINT CO., LTD. (JP) | 2003-03-18 | — | — | US | claimed |
| US-20020137878-A1 | Process for producing alkyd resins | ITO KEI (JP) | 2002-09-26 | — | — | US | claimed |
| US-5631248-A | TWO LIQUIDS WITH DIFFERENT LIPOPHILICITIES, DISSOLVED DRUG | SMITHKLINE BEECHAM PLC (GB) | 1997-05-20 | — | — | US | claimed |
| EP-0634925-B1 | SUPERSATURATED TOPICAL COMPOSITIONS | SMITHKLINE BEECHAM PLC (GB) | 1996-01-17 | — | — | EP | claimed |
| EP-0428249-B1 | Transesterification of triglycerides | SANKARAN VISWANATHA (IN) | 1995-06-21 | — | — | EP | claimed |
| EP-0634925-A1 | SUPERSATURATED TOPICAL COMPOSITIONS. | SMITHKLINE BEECHAM PLC (GB) | 1995-01-25 | — | — | EP | claimed |
| WO-1993020799-A1 | SUPERSATURATED TOPICAL COMPOSITIONS | SMITHKLINE BEECHAM PLC (GB) | 1993-10-28 | — | — | WO | claimed |
| US-20240222631-A1 | CATHODE, LITHIUM SECONDARY BATTERY INCLUDING THE SAME, AND METHOD OF PREPARING CATHODE | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2024-07-04 | — | — | US | disclosed |
| CN-113805253-B | Structurally colored articles and methods for making and using the same | 耐克创新有限合伙公司 | 2024-04-09 | — | — | CN | disclosed |
| US-4254228-A | Method of making foamed resins with internal mold-release agents | BAYER AKTIENGESELLSCHAFT (DE) | 1981-03-03 | — | — | US | disclosed |
| US-4201847-A | Process of preparing foams with internal mold-release agents | BAYER AKTIENGESELLSCHAFT (DE) | 1980-05-06 | — | — | US | disclosed |
| US-4145264-A | AROMATIC O-DICARBOXYLIC ACID NITRILES ELECTROLYZED IN AN ORGANIC LIQUID WITH AN ALKALINE ACTIVATOR | BASF AKTIENGESELLSCHAFT (DE) | 1979-03-20 | — | — | US | disclosed |