Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31696340 | 1.00 | KDM4E (0.38) | KDM4EHSP90AA1HSP90AB1L3MBTL1CYP1A2 | |
| SCHEMBL26174058 | 0.84 | ALDH1A1 (0.39) | KDM4EHSP90AA1HSP90AB1L3MBTL1CYP1A2 | |
| SCHEMBL29005499 | 0.84 | KDM4E (0.37) | KDM4EHSP90AA1HSP90AB1L3MBTL1CYP1A2 | |
| SCHEMBL3655719 | 0.83 | ATR (0.41) | ATRLMNAGRM5RAB9ANPC1 | |
| SCHEMBL21827373 | 0.82 | PTK2 (0.41) | KDM4EHSP90AA1HSP90AB1L3MBTL1DYRK1A | |
| SCHEMBL31471197 | 0.82 | PTK2 (0.41) | KDM4EHSP90AA1HSP90AB1L3MBTL1DYRK1A | |
| SCHEMBL29522634 | 0.81 | TDP1 (0.38) | ATRGRM5 | |
| SCHEMBL19387669 | 0.81 | NPSR1 (0.40) | KDM4ECYP1A2ATRRAB9AALDH1A1 | |
| SCHEMBL7912863 | 0.81 | KDM4E (0.35) | KDM4EHSP90AA1HSP90AB1L3MBTL1CYP1A2 | |
| SCHEMBL138438 | 0.79 | JAK3 (0.35) | ATRLMNAPOLBGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724070-A2 | WRN INHIBITORS | Nimbus Wadjet, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| WO-2025137599-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| US-20250206738-A1 | WRN INHIBITORS | NIMBUS DISCOVERY, INC. | 2025-06-26 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171440-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024254511-A2 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| WO-2023100942-A1 | COMPOUND FOR PHOTOOXYGENATION CATALYST AND MEDICINAL COMPOSITION CONTAINING SAME | 国立大学法人 東京大学 | 2023-06-08 | — | — | WO | disclosed |
| EP-1831184-B1 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | WELLCOME TRUST LTD (GB) | 2011-02-09 | — | — | EP | disclosed |
| US-7737152-B2 | 6-carboaryl-oxy-pyrazin-2-yl-carboaryl-amines and compositions comprising said compounds | THE WELLCOME TRUST LIMITED (GB) | 2010-06-15 | — | — | US | disclosed |
| US-20080015191-A1 | Pyrazines and Pyridines and Derivatives Thereof as Therapeutic Compounds | THE WELLCOME TRUST LIMITED (UK) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206738-A1 | WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 3350/4885HSP90AA1 554/4885HSP90AB1 432/4885 |
| US-20250171440-A1 | WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 2662/4885HSP90AA1 759/4885HSP90AB1 554/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 3350/4885HSP90AA1 554/4885HSP90AB1 432/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | KDM4E 3350/4885HSP90AA1 554/4885HSP90AB1 432/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | KDM4E 2662/4885HSP90AA1 759/4885HSP90AB1 554/4885 |
| US-20080015191-A1 | Pyrazines and Pyridines and Derivatives Thereof as Therapeutic Compounds | BRAF, RAF1, BCOR | KDM4E 2382/4885HSP90AA1 2077/4885HSP90AB1 1638/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 3350/4885HSP90AA1 554/4885HSP90AB1 432/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 3415/4885HSP90AA1 543/4885HSP90AB1 427/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | KDM4E 1099/4885HSP90AA1 1546/4885HSP90AB1 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.