Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840228 | 0.92 | KDM4E (0.48) | MAPK1KDM4EHIF1APAOXTSHR | |
| SCHEMBL10858021 | 0.91 | KDM4E (0.57) | MAPK1KDM4EHIF1APAOXTSHR | |
| SCHEMBL11614892 | 0.81 | KDM4E (0.46) | MAPK1KDM4EHIF1APAOXTSHR | |
| SCHEMBL11358449 | 0.80 | ECE1 (0.42) | KDM4ETSHRADRA1A | |
| SCHEMBL11444958 | 0.78 | PAOX (0.46) | MAPK1KDM4EHIF1APAOXTSHR | |
| SCHEMBL11398140 | 0.77 | ADRA1A (0.44) | MAPK1TSHRADRA1AALDH1A1SMN1; SMN2 | |
| SCHEMBL11434568 | 0.77 | POLB (0.36) | L3MBTL1 | |
| SCHEMBL4531919 | 0.76 | KDM4E (0.50) | MAPK1KDM4EHIF1APAOXTSHR | |
| SCHEMBL11392566 | 0.75 | EGLN1 (0.48) | KDM4EHIF1ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL11388023 | 0.74 | ADRA1A (0.55) | MAPK1ADRA1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018669-B1 | 1-(2-SULFAMOYLAMINOETHYL)-1,4-DIHYDRO-5H-TETRAZOLE-5-THIONE AND ITS SALTS | SMITHKLINE BECKMAN CORPORATION (US) | 1982-04-14 | — | — | EP | disclosed |
| EP-0000100-B1 | 7-ACYLAMINO-3-(1-(2-SULFAMOYLAMINOETHYL)-TETRAZOL-5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACIDS, A PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1982-02-03 | — | — | EP | disclosed |
| EP-0018669-A1 | 1-(2-Sulfamoylaminoethyl)-1,4-dihydro-5H-tetrazole-5-thione and its salts | SMITHKLINE BECKMAN CORPORATION (US) | 1980-11-12 | — | — | EP | disclosed |
| US-4205166-A | 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-05-27 | — | — | US | disclosed |
| US-4178288-A | Sulfaminoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins | SMITHKLINE CORPORATION (US) | 1979-12-11 | — | — | US | disclosed |
| US-4174323-A | BACTERICIDE, CEPHALOSPORIN INTERMEDIATES | SMITHKLINE CORPORATION (US) | 1979-11-13 | — | — | US | disclosed |
| US-4171368-A | 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4171433-A | 7-Amino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporin intermediates for preparing 7-acylamino cephalosporins | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| US-4171362-A | 7-Acylamino-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1979-10-16 | — | — | US | disclosed |
| EP-0000100-A1 | 7-Acylamino-3-(1-(2-sulfamoylaminoethyl)-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids, a process for their preparation and compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1978-12-20 | — | — | EP | disclosed |
| US-4118491-A | 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1978-10-03 | — | — | US | disclosed |
| US-4117123-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1978-09-26 | — | — | US | disclosed |
| US-4101656-A | 7β-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them | SMITHKLINE CORPORATION (US) | 1978-07-18 | — | — | US | disclosed |
| US-4096256-A | ANTIBIOTICS | SMITHKLINE CORPORATION (US) | 1978-06-20 | — | — | US | disclosed |
| US-4068073-A | BACTERICIDES | SMITHKLINE CORPORATION (US) | 1978-01-10 | — | — | US | disclosed |
| US-4066762-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |
| US-4066761-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |
| US-4059591-A | Ureidoalkyl substituted tetrazole thiol intermediates for preparing cephalosporins | SMITHKLINE CORPORATION (US) | 1977-11-22 | — | — | US | disclosed |
| US-4025626-A | ANTIBACTERIAL | SMITHKLINE CORPORATION (US) | 1977-05-24 | — | — | US | disclosed |