Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 8/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11351356 | 0.90 | ESR1 (0.54) | OXER1ESR1PARP1ADAMTS5NAMPT | |
| SCHEMBL11348655 | 0.85 | ESR1 (0.56) | ESR1PARP1APLNRADAMTS5NAMPT | |
| SCHEMBL11239836 | 0.84 | ESR1 (0.56) | ESR1PARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL11239643 | 0.83 | ESR1 (0.57) | ESR1PARP1ADAMTS5 | |
| SCHEMBL11348685 | 0.79 | ESR1 (0.58) | ESR1PARP1ADAMTS5NAMPTMAPK10 | |
| SCHEMBL11239440 | 0.77 | KMT2A (0.53) | ESR1SMN1; SMN2 | |
| SCHEMBL4198757 | 0.76 | NAMPT (0.65) | ESR1PARP1ADAMTS5NAMPTSMN1; SMN2 | |
| SCHEMBL11335727 | 0.76 | ESR1 (0.61) | ESR1PARP1ADAMTS5MAPK10SMN1; SMN2 | |
| SCHEMBL6245254 | 0.75 | NAMPT (0.64) | ESR1PARP1ADAMTS5NAMPTSMN1; SMN2 | |
| SCHEMBL11247608 | 0.74 | ESR1 (0.48) | ESR1PARP1ADAMTS5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |