Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11239440 | 0.92 | KMT2A (0.53) | ESR1ALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL11247608 | 0.90 | ESR1 (0.48) | ESR1ALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL11348678 | 0.88 | AVPR1A (0.48) | ESR1KMT2APARP1PKM | |
| SCHEMBL11239643 | 0.88 | ESR1 (0.57) | ESR1PARP1 | |
| SCHEMBL11351356 | 0.87 | ESR1 (0.54) | ESR1ALDH1A1MAPTPARP1SMN1; SMN2 | |
| SCHEMBL11347461 | 0.86 | ALDH1A1 (0.53) | ESR1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11223035 | 0.84 | OXER1 (0.55) | ESR1PARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL11335727 | 0.83 | ESR1 (0.61) | ESR1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL11785959 | 0.82 | GAA (0.68) | ESR1ALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL11242790 | 0.78 | KMT2A (0.50) | ESR1ALDH1A1KMT2APARP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |