Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11228422 | 0.97 | PDE3B (0.49) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11249495 | 0.87 | PDE3B (0.51) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11246399 | 0.84 | PDE3B (0.52) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11247774 | 0.84 | PDE3B (0.52) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11231275 | 0.82 | PDE3B (0.41) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11236000 | 0.81 | PDE3B (0.49) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11223228 | 0.81 | PDE3B (0.49) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11227656 | 0.80 | PDE3B (0.53) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11229942 | 0.80 | PDE3B (0.58) | PDE3BPDE3ACDK5CDK5R1CDC7 | |
| SCHEMBL11240589 | 0.79 | PDE3B (0.60) | PDE3BPDE3ACDK5CDK5R1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339584-A | Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones via N-hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide by reaction with polyphosphoric acid | STERLING DRUG INC. (US) | 1982-07-13 | — | — | US | disclosed |
| US-4305948-A | N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |