Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | CDC7 | O00311 | 8/20 | 0.49 |
| ▸ | CCNC | P24863 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246399 | 0.96 | PDE3B (0.52) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11240589 | 0.91 | PDE3B (0.60) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11247774 | 0.89 | PDE3B (0.52) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11223231 | 0.87 | PDE3B (0.48) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11078652 | 0.86 | CDC7 (0.61) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11236000 | 0.86 | PDE3B (0.49) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL11227656 | 0.85 | PDE3B (0.53) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11223228 | 0.84 | PDE3B (0.49) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL11228422 | 0.84 | PDE3B (0.49) | PDE3BPDE3ACDC7CCNCCDK8 | |
| SCHEMBL11229942 | 0.83 | PDE3B (0.58) | PDE3BPDE3ACDC7CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |