Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11403878 | 1.00 | TSHR (0.36) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL11222380 | 0.83 | ALOX15 (0.36) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL10987409 | 0.83 | ALOX15 (0.53) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL11232050 | 0.83 | ALOX15 (0.36) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL8344796 | 0.81 | TSHR (0.43) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL11337479 | 0.77 | ALOX15 (0.34) | ALOX15CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL11089407 | 0.77 | ALOX15 (0.39) | TSHRALOX15LMNACYP2C19CYP1A2 | |
| SCHEMBL11089412 | 0.77 | ALOX15 (0.39) | TSHRALOX15LMNACYP2C19CYP1A2 | |
| SCHEMBL8256063 | 0.77 | TSHR (0.40) | TSHRGAAEGFRHSD17B10MGAM | |
| SCHEMBL11145460 | 0.77 | ALOX15 (0.39) | TSHRALOX15LMNACYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007142-B1 | NOVEL INTERMEDIATES IN THE PREPARATION OF CYCLOPROPANECARBOXYLATE ESTERS AND PROCESS FOR THEIR MANUFACTURE | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-05-12 | — | — | EP | disclosed |