Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 5/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72229 | 0.84 | ACE (0.48) | ACELTA4HCA12CA1CA2 | |
| SCHEMBL72230 | 0.84 | ACE (0.48) | ACELTA4HCA12CA1CA2 | |
| SCHEMBL18098146 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H | |
| SCHEMBL21375005 | 0.73 | ACE (0.59) | ACEMMECPA1ACE2 | |
| SCHEMBL6468859 | 0.73 | ACE (0.59) | ACEMMECPA1ACE2 | |
| SCHEMBL23142762 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H | |
| SCHEMBL15307782 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H | |
| SCHEMBL13598642 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H | |
| SCHEMBL13165106 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H | |
| SCHEMBL15080628 | 0.73 | MME (0.48) | ACEMMECPA1ACE2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316896-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0009183-B1 | PHOSPHORYL AMINOACID DERIVATIVES AND COMPOSITION FOR TREATING HYPERTENSION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0009183-A1 | Phosphoryl aminoacid derivatives and composition for treating hypertension containing the same | MERCK & CO. INC. (US) | 1980-04-02 | — | — | EP | disclosed |