Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.57 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23709817 | 0.97 | RHEB (0.94) | RHEBKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL30615082 | 0.84 | RHEB (0.73) | RHEBKDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL9000174 | 0.84 | RHEB (0.73) | RHEBKDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL30943399 | 0.81 | RHEB (0.69) | RHEBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10736415 | 0.81 | RHEB (0.69) | RHEBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6324494 | 0.81 | RHEB (0.69) | RHEBKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL25206796 | 0.81 | RHEB (0.69) | RHEBKDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL7164766 | 0.81 | KDM4E (0.73) | RHEBKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL7164761 | 0.81 | RHEB (0.69) | RHEBKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL24075038 | 0.81 | RHEB (0.68) | RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336257-A | XANTHINE OXIDASE INHIBITORS OR ANTIHYPERTENSIVE AGENTS | MERCK & CO., INC. (US) | 1982-06-22 | — | — | US | claimed |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-4336257-A | XANTHINE OXIDASE INHIBITORS OR ANTIHYPERTENSIVE AGENTS | MERCK & CO., INC. (US) | 1982-06-22 | — | — | US | disclosed |
| US-4281005-A | XANTHINE OXIDASE INHIBITORS AND AS ANTIHYPERTENSIVE | MERCK & CO., INC. (US) | 1981-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | RHEB 1/4885KDM4E 2462/4885ALDH1A1 3621/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | RHEB 1/4885KDM4E 3566/4885ALDH1A1 3277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.