Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2263853 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16704813 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16704798 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2265585 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1961397 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16705141 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6099950 | 0.86 | POLB (0.42) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20434234 | 0.80 | POLB (0.39) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14450705 | 0.74 | POLB (1.00) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14529762 | 0.74 | POLB (1.00) | TDP1POLBAPEX1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347254-A | Tricyclic cage compounds, their synthesis and use as antiviral agents | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-08-31 | — | — | US | disclosed |