Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483156 | 0.84 | HRH3 (0.52) | EPHX2PDE3BPDE3APDE10ARET | |
| SCHEMBL11234139 | 0.84 | NAAA (0.53) | EPHX2LMNAMAPTHRH3 | |
| SCHEMBL29605026 | 0.81 | AVPR1A (0.49) | EPHX2LMNAAVPR1AKCNH2HCRTR1 | |
| SCHEMBL20266971 | 0.81 | AVPR1A (0.49) | EPHX2LMNAAVPR1AKCNH2HCRTR1 | |
| SCHEMBL29718374 | 0.81 | EPHX2 (0.49) | EPHX2PDE3BPDE3APDE10ARIPK1 | |
| SCHEMBL20412701 | 0.81 | EPHX2 (0.49) | EPHX2PDE3BPDE3APDE10ARIPK1 | |
| SCHEMBL2743227 | 0.81 | PDE3B (0.50) | EPHX2PDE3BPDE3APDE10ARIPK1 | |
| SCHEMBL20158605 | 0.81 | EPHX2 (0.49) | EPHX2PDE3BPDE3APDE10ARIPK1 | |
| SCHEMBL24871430 | 0.80 | MEN1 (0.51) | EPHX2PDE3BPDE3APDE10ASCN9A | |
| SCHEMBL5152829 | 0.79 | EPHX2 (0.63) | EPHX2RIPK1SCN9AHRH3KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4325953-A | 4-Aryl-4-aryloxypiperidines | JOHN WYETH AND BROTHER LIMITED (GB) | 1982-04-20 | — | — | US | claimed |
| US-4325953-A | 4-Aryl-4-aryloxypiperidines | JOHN WYETH AND BROTHER LIMITED (GB) | 1982-04-20 | — | — | US | disclosed |