Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450515 | 0.82 | AURKA (0.61) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL27667117 | 0.81 | ERCC1 (0.57) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL11239434 | 0.77 | CCNC (0.55) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL11242759 | 0.76 | KDM4E (0.58) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL11453577 | 0.76 | KDM4E (0.46) | KDM4EMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL11249414 | 0.73 | KDM4E (0.50) | KDM4EMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL11450001 | 0.73 | TTK (0.64) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL14213391 | 0.73 | TTK (0.64) | TTKAURKBINCENPKDM4EAURKA | |
| Inamrinone SCHEMBL44012 | 0.73 | AURKB (1.00) | TTKAURKBINCENPKDM4EAURKA | |
| SCHEMBL11292011 | 0.73 | ERCC1 (0.64) | TTKAURKBINCENPKDM4EAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | claimed |
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4309537-A | Production of imidazo[4,5-b]pyridin-2-ones or thiones | STERLING DRUG INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4297360-A | 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4294837-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4276293-A | Compositions and their preparation | STERLING DRUG INC. (US) | 1981-06-30 | — | — | US | disclosed |
| US-4225715-A | Preparation of 3-amino(or carbamyl)-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4199586-A | Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates | STERLING DRUG INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4137233-A | 1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides | STERLING DRUG INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4107315-A | 5-(Pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4004012-A | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1977-01-18 | — | — | US | disclosed |