Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448667 | 0.78 | AURKB (0.56) | KDM4EPRMT5WDR77MAPTALDH1A1 | |
| SCHEMBL11453577 | 0.77 | KDM4E (0.46) | KDM4EPRMT5WDR77MAPTALDH1A1 | |
| SCHEMBL11235175 | 0.75 | PTGS1 (0.45) | KDM4EPAX8MAPTALDH1A1MEN1 | |
| SCHEMBL11458186 | 0.75 | MCL1 (0.56) | KDM4EPRMT5WDR77ALDH1A1MKNK1 | |
| SCHEMBL11456663 | 0.75 | DHODH (0.50) | KDM4EPRMT5WDR77MAPTALDH1A1 | |
| SCHEMBL11450515 | 0.74 | AURKA (0.61) | KDM4EALDH1A1L3MBTL1RAB9ALMNA | |
| SCHEMBL11448108 | 0.74 | MKNK1 (0.55) | PRMT5WDR77MKNK1MKNK2TDO2 | |
| SCHEMBL4973565 | 0.73 | TRPV1 (0.51) | KDM4E | |
| SCHEMBL11227729 | 0.73 | TTK (0.57) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11239434 | 0.72 | CCNC (0.55) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4225715-A | Preparation of 3-amino(or carbamyl)-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4199586-A | Di-(lower-alkyl) N-[1,2-dihydro-2-oxo-5-(pyridinyl)-3-pyridinyl]amino-methylanemalonates | STERLING DRUG INC. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4137233-A | 1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides | STERLING DRUG INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4107315-A | 5-(Pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4072746-A | CARDIOTONIC AGENTS | STERLING DRUG INC. (US) | 1978-02-07 | — | — | US | disclosed |
| US-4004012-A | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1977-01-18 | — | — | US | disclosed |