SCHEMBL11228484

SCHEMBL11228484

ClCSCc1ccc(Cl)cc1Cl

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.80
CYP3A4 P08684 2/20 0.80
CYP2C19 P33261 2/20 0.80
CYP2C9 P11712 1/20 0.80
MAPK1 P28482 1/20 0.80
ALDH1A1 P00352 3/20 0.54
POLB P06746 1/20 0.54
IDO1 P14902 9/20 0.53
HTT P42858 3/20 0.53
GAA P10253 2/20 0.47
PKM P14618 1/20 0.47
MAPT P10636 2/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
CYP2D6 P10635 1/20 0.44
ALOX12 P18054 1/20 0.44
EPHX1 P07099 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4863737 0.89 CYP1A2 (1.00) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL11229601 0.87 CYP1A2 (0.61) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL10953834 0.79 CYP1A2 (0.71) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL10724739 0.79 CYP1A2 (0.71) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL11742336 0.77 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL11709033 0.77 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL6011647 0.77 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL11353946 0.77 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL2339033 0.76 ALDH1A1 (0.68) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1
SCHEMBL283639 0.75 IDO1 (0.62) CYP1A2CYP3A4CYP2C19CYP2C9MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4315023-A FOR USE AS FUNGICIDES AND BACTERICIDES WESTWOOD PHARMACEUTICALS, INC. (US) 1982-02-09 US disclosed
EP-0000752-B1 ALPHA-AZOLYLSULPHIDES, SULPHOXIDES AND SULPHONES, THEIR SALTS AND METAL COMPLEXES, METHOD FOR THEIR PRODUCTION AND FUNGIZIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1981-01-14 EP disclosed
EP-0000752-A2 Alpha-azolylsulphides, sulphoxides and sulphones, their salts and metal complexes, method for their production and fungizides containing them BASF Aktiengesellschaft (DE) 1979-02-21 EP disclosed