Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 6/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | TTK | P33981 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11228960 | 1.00 | ITK (0.46) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11234330 | 0.82 | TTK (0.51) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11234332 | 0.82 | TTK (0.51) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11219799 | 0.81 | ITK (0.61) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11219801 | 0.81 | ITK (0.61) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11228315 | 0.81 | ITK (0.44) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11228318 | 0.81 | ITK (0.44) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11233679 | 0.81 | ITK (0.41) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11233683 | 0.81 | ITK (0.41) | ITKGPR142KITSRCFLT3 | |
| SCHEMBL11231636 | 0.74 | CCNC (0.48) | ITKGPR142KITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362735-A | 3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1982-12-07 | — | — | US | disclosed |