Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231128 | 0.87 | MKNK1 (0.49) | PDE3BPDE3AMKNK1MKNK2CDC7 | |
| SCHEMBL11229059 | 0.84 | MKNK1 (0.43) | PDE3BPDE3AMKNK1MKNK2CYP2C19 | |
| SCHEMBL11234641 | 0.83 | PDE3B (0.44) | PDE3BPDE3AMKNK1MKNK2CYP2E1 | |
| SCHEMBL11236049 | 0.81 | CCNC (0.41) | PDE3BPDE3AMKNK2CDC7 | |
| SCHEMBL11231551 | 0.80 | AURKB (0.51) | PDE3BPDE3AMKNK1MKNK2CYP2E1 | |
| SCHEMBL11233012 | 0.80 | PDE3B (0.42) | PDE3BPDE3AMKNK1MKNK2CYP2E1 | |
| SCHEMBL11236586 | 0.79 | CDK5 (0.53) | PDE3BPDE3ACDC7KDM4EALDH1A1 | |
| SCHEMBL11235886 | 0.78 | PDE3B (0.46) | PDE3BPDE3AMKNK1MKNK2CYP2E1 | |
| SCHEMBL11228422 | 0.76 | PDE3B (0.49) | PDE3BPDE3ACDC7AURKBINCENP | |
| SCHEMBL11223231 | 0.75 | PDE3B (0.48) | PDE3BPDE3ACDC7AURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339584-A | Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones via N-hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide by reaction with polyphosphoric acid | STERLING DRUG INC. (US) | 1982-07-13 | — | — | US | disclosed |
| US-4305948-A | N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |