Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28222937 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 | |
| SCHEMBL11233372 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 | |
| SCHEMBL566341 | 0.87 | ALDH1A1 (0.44) | MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1307988 | 0.87 | ALDH1A1 (0.44) | MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL186779 | 0.87 | ALDH1A1 (0.44) | MAPTL3MBTL1ALDH1A1 | |
| Acrolein SCHEMBL18954138 | 0.80 | AKT1 (0.42) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11879607 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 | |
| SCHEMBL9472917 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 | |
| SCHEMBL28370611 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 | |
| SCHEMBL28370610 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTL3MBTL1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344966-A | Anti-inflammatory 1-alkyl-1-phenyl-butanes | SANDOZ, INC. (US) | 1982-08-17 | — | — | US | disclosed |
| US-4081476-A | ANTIINFLAMMATORY | SANDOZ, INC. (US) | 1978-03-28 | — | — | US | disclosed |