Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.37 |
| ▸ | KDM6B | O15054 | 4/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19840668 | 0.82 | KDM4C (0.44) | KDM4CKDM6BKDM4EALDH1A1TDP1 | |
| SCHEMBL16684319 | 0.76 | KDM4C (0.41) | KDM4CKDM6BCYP2E1CYP2C8CYP2D6 | |
| Bromide SCHEMBL16671695 | 0.74 | KDM4C (0.40) | CCNCCDK8KDM4CKDM6BCYP2E1 | |
| SCHEMBL11236770 | 0.73 | KDM4C (0.44) | KDM4CKDM6BCYP2E1CYP2C8CYP2D6 | |
| SCHEMBL30100781 | 0.73 | KDM4C (0.56) | KDM4CKDM6BKDM4EALDH1A1TDP1 | |
| SCHEMBL115648 | 0.73 | KDM4C (0.56) | KDM4CKDM6BKDM4EALDH1A1TDP1 | |
| SCHEMBL11088722 | 0.72 | CYP1A2 (0.48) | CYP2D6CYP2A6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL8594489 | 0.72 | TDP1 (0.56) | CCNCCDK8KDM4CKDM6BCYP2E1 | |
| SCHEMBL1026384 | 0.72 | KDM4C (0.42) | KDM4CKDM6BCYP2E1CYP2C8CYP2D6 | |
| Hydrochloric Acid SCHEMBL1026385 | 0.72 | KDM4C (0.54) | KDM4CKDM6BKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4354026-A | 3-Chloro-6-(pyridinyl)-pyridazines | STERLING DRUG INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304775-A | 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |