SCHEMBL11233907

SCHEMBL11233907

Cc1ccc(Br)cc1N=C=O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.63
TRPA1 O75762 1/20 0.63
ALDH1A1 P00352 5/20 0.38
HPGD P15428 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
SIGMAR1 Q99720 2/20 0.33
LMNA P02545 2/20 0.33
PYCR1 P32322 1/20 0.33
MAPT P10636 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
USP2 O75604 1/20 0.33
RAB9A P51151 1/20 0.33
BLM P54132 1/20 0.33
KMT2A Q03164 1/20 0.33
MAPK1 P28482 2/20 0.31
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
HSP90AA1 P07900 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1021321 0.84 CYP3A4 (0.48) CYP3A4TRPA1ALDH1A1HPGDTDP1
SCHEMBL31597 0.79 CYP3A4 (0.68) CYP3A4TRPA1ALDH1A1HPGDTDP1
SCHEMBL10869858 0.79 CYP3A4 (0.68) CYP3A4TRPA1ALDH1A1HPGDTDP1
Toluene Diisocyanate SCHEMBL29737260 0.78 CYP3A4 (1.00) CYP3A4TRPA1ALDH1A1HPGDTDP1
SCHEMBL27900818 0.78 CYP3A4 (0.66) CYP3A4TRPA1ALDH1A1HPGDTDP1
Toluene Diisocyanate SCHEMBL29350148 0.78 CYP3A4 (1.00) CYP3A4TRPA1ALDH1A1HPGDTDP1
Toluene Diisocyanate SCHEMBL15384 0.78 CYP3A4 (1.00) CYP3A4TRPA1ALDH1A1HPGDTDP1
Toluene Diisocyanate SCHEMBL28174227 0.78 CYP3A4 (1.00) CYP3A4TRPA1ALDH1A1HPGDTDP1
Toluene Diisocyanate SCHEMBL19733056 0.78 CYP3A4 (1.00) CYP3A4TRPA1ALDH1A1HPGDTDP1
SCHEMBL13645354 0.77 GABRA1 (0.44) CYP3A4TRPA1ALDH1A1HPGDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4348413-A Anti-arrhythmic N-[3-alkylaminopropyl]-N'-phenylureas AMERICAN HOME PRODUCTS CORPORATION (US) 1982-09-07 US disclosed
EP-0007184-B1 UREA DERIVATIVES, PROCESSES FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM AMERICAN HOME PRODUCTS CORPORATION (US) 1982-06-30 EP disclosed
WO-1980000151-A1 N-(3-ALKYLAMINOPROPYL)-N'-PHENYLUREAS AMERICAN HOME PROD (US) 1980-02-07 WO disclosed
EP-0007184-A1 Urea derivatives, processes for preparing them and compositions containing them AMERICAN HOME PRODUCTS CORPORATION (US) 1980-01-23 EP disclosed