Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 2/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11222561 | 0.89 | MAPT (0.57) | ABCB1MAPTNPSR1ABCC1HTT | |
| SCHEMBL11225695 | 0.86 | PIK3C3 (0.48) | ABCB1MAPTNPSR1ABCC1PDE7A | |
| SCHEMBL11224541 | 0.84 | ABCB1 (0.54) | HDAC1HDAC3HDAC2ABCB1MAPT | |
| SCHEMBL11224373 | 0.83 | MAPT (0.47) | HDAC1ABCB1MAPTNPSR1ABCC1 | |
| SCHEMBL11220980 | 0.82 | KMT2A (0.43) | ABCB1MAPTNPSR1ABCC1PDE7A | |
| SCHEMBL4314789 | 0.82 | ABCB1 (0.55) | ABCB1MAPTNPSR1ABCC1NPC1 | |
| SCHEMBL11224469 | 0.80 | PIK3C3 (0.44) | HDAC1ABCB1MAPTNPSR1ABCC1 | |
| SCHEMBL11225688 | 0.79 | KMT2A (0.44) | ABCB1MAPTNPSR1ABCC1PDE7A | |
| SCHEMBL11277648 | 0.77 | MAPT (0.53) | ABCB1MAPTNPSR1ABCC1HTT | |
| SCHEMBL2282371 | 0.77 | MAPT (0.68) | ABCB1MAPTNPSR1ABCC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056260-A1 | Pyridinyl-substituted-benz imidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-21 | — | — | EP | disclosed |
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |
| US-4331671-A | 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4297362-A | 4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardiotonic | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |
| US-4297362-A | 4-(3,4-Diaminophenyl)pyridine or salts, and use thereof as cardiotonic | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |