Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287679 | 0.90 | ABCB1 (0.66) | ABCB1ABCC1PIK3CAPIK3CGMEN1 | |
| SCHEMBL11233932 | 0.84 | HDAC1 (0.48) | ABCB1ABCC1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11224469 | 0.84 | PIK3C3 (0.44) | ABCB1ABCC1MEN1KMT2AHDAC1 | |
| SCHEMBL13833495 | 0.82 | HDAC1 (0.69) | ABCB1ABCC1CYP11B1CYP11B2HDAC1 | |
| SCHEMBL11225695 | 0.80 | PIK3C3 (0.48) | ABCB1ABCC1KMT2ANPC1MAPT | |
| SCHEMBL11224373 | 0.79 | MAPT (0.47) | ABCB1ABCC1MEN1KMT2AHDAC1 | |
| SCHEMBL7466534 | 0.79 | ABCB1 (0.64) | ABCB1ABCC1CYP11B1CYP11B2MEN1 | |
| SCHEMBL1663904 | 0.78 | CYP11B1 (0.57) | ABCB1ABCC1CYP11B1CYP11B2MEN1 | |
| SCHEMBL2203423 | 0.77 | MAPT (0.54) | ABCB1ABCC1CYP11B1CYP11B2MEN1 | |
| SCHEMBL11371966 | 0.77 | MKNK1 (0.55) | ABCB1ABCC1CYP11B1CYP11B2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056260-A1 | Pyridinyl-substituted-benz imidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-21 | — | — | EP | disclosed |
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |
| US-4331671-A | 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |