Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.49 |
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11627503 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11035016 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11714525 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10353452 | 0.73 | SMN1; SMN2 (0.81) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL21969537 | 0.72 | SMN1; SMN2 (0.62) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL12595771 | 0.72 | PDE3B (0.61) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11247281 | 0.72 | SMN1; SMN2 (0.67) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10899885 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL12527726 | 0.72 | CYP2A6 (0.46) | CYP11B2CYP11B1 | |
| SCHEMBL7306728 | 0.71 | PDE3B (0.60) | SMN1; SMN2PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4338446-A | Di-(lower-alkyl)hydroxy-[2-oxo-2-(pyridinyl)ethyl]-propanedioates | STERLING DRUG INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4304776-A | 4-Substituted-6-(pyridinyl)-3(2h)-pyridazinones and their use as intermediates and cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4304777-A | 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |