Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237109 | 0.93 | POLB (0.41) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11234052 | 0.92 | HMOX1 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL11242164 | 0.89 | POLB (0.42) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11243716 | 0.87 | POLB (0.44) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11248376 | 0.86 | CYP11B1 (0.46) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11237414 | 0.86 | HMOX1 (0.44) | — | |
| SCHEMBL11229193 | 0.85 | CYP19A1 (0.45) | CYP11B1CYP11B2QPCTALDH1A1 | |
| SCHEMBL11244474 | 0.85 | POLB (0.43) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11239088 | 0.84 | CYP11B1 (0.49) | POLBCTDSP1TDP1TSHRKMT2A | |
| SCHEMBL11249026 | 0.83 | CYP11B1 (0.39) | POLBCTDSP1TDP1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |